PACS1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000512
Fusion event
HBV-PACS1 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr11
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
65896547/66129076 (Hg38)
End
65896547/66129076 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
PACS1
miRNAs that regulate target gene
hsa-mir-324-5p ; hsa-mir-320a ; hsa-mir-218-5p ; hsa-mir-6869-5p ; hsa-mir-526b-5p ; hsa-mir-431-5p ; hsa-mir-4711-5p ; hsa-mir-935 ; hsa-mir-3662 ; hsa-mir-6513-5p ; hsa-mir-599 ; hsa-mir-5089-5p ; hsa-mir-6728-5p ; hsa-mir-769-3p ; hsa-mir-450b-3p ; hsa-mir-3145-3p ; hsa-mir-610 ; hsa-mir-3614-5p ; hsa-mir-4461 ; hsa-mir-6079 ; hsa-mir-6077 ; hsa-mir-7-5p ; hsa-mir-9-5p ; hsa-mir-8485 ; hsa-mir-1200 ; hsa-mir-4284 ; hsa-mir-4772-3p ; hsa-mir-4682 ; hsa-mir-3653-5p ; hsa-mir-1304-3p ; hsa-mir-544b ; hsa-mir-4324 ; hsa-mir-660-3p ; hsa-mir-6890-3p ; hsa-mir-1306-5p ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-6741-3p ; hsa-mir-2861 ; hsa-mir-3134 ; hsa-mir-449b-3p ; hsa-mir-4534 ; hsa-mir-602 ; hsa-mir-6081 ; hsa-mir-6749-5p ; hsa-mir-8082
Nearest miRNA
hsa-mir-10392/Upstream/479823; hsa-let-7a-2/Downstream/805358;
Nearest TSS
ENST00000527297/Upstream/28313; ENST00000531298/Downstream/87122;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/57898, chr11-CpG: 120/Downstream/128363
Downstream sequence
AATGTGTGTATTTTATTGTATGTAAATTATACTGTAATGTCAATTTAAAAATTGATTAAAGTTAGTAAGAAGGGTCCAGGTG
Target sequence
TATAAAATTTTAAAGGCAAAGGGAATCGGGAAAAA
Junction sequence
TATGTAATTGGATGTTGGGGTACTTTACCGCAAGAACACATTGTACTAAAAATCAAGCAATGTTTTCGAAAATGTGTGTATTTTATTGTATGTAAATTATACTGTAATGTCAATTTAAAAATTGATTAAAGTTAGTAAGAAGGGTCCAGGTG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
Curate