Basic Information
VIS ID
TVIS10000518
Fusion event
HBV-chr18 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr18
Cytoband
q11.1
Reference genome
GRCh37/hg19
Start
18517552/20937591 (Hg38)
End
18517552/20937591 (Hg38)
Nearest miRNA
hsa-mir-3156-2/Upstream/6107349; hsa-mir-1-2/Downstream/745927;
Nearest TSS
ENST00000575820/Upstream/5773124; ENST00000579454/Downstream/17279;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/5606416, chr18-CpG: 113/Downstream/173388
Nearby gene
ROCK1(+12151) ;
Nearest cancer related gene
ROCK1(OG, +12151) ;
Upstream sequence
CCATATCACCTGCAGATTCTACAAAAGGAGTGTTTCCAAAATGCTGTATCAAAACCAAAGTTCAACTCTGTTAGTTGAGGACACACATCACAAATAAGTTTCTGAGAATGCTTCTGTCTAGATTCTATATGAAGATATCCCCTTTCCAACGAATCCCTCTAAGCTATCCAAATATCCACCTGCAGATTCTACAAAAAGAGTGTTTCCAAAATGCTGTATCAAAACAAAGTTTCAACTCTGTTAGTTGAGGACACACATCACAAATAAGTTTGAGGATGCTTCTGTCTAGTTTTTA
Junction sequence
CCATATCACCTGCAGATTCTACAAAAGGAGTGTTTCCAAAATGCTGTATCAAAACCAAAGTTCAACTCTGTTAGTTGAGGACACACATCACAAATAAGTTTCTGAGAATGCTTCTGTCTAGATTCTATATGAAGATATCCCCTTTCCAACGAATCCCTCTAAGCTATCCAAATATCCACCTGCAGATTCTACAAAAAGAGTGTTTCCAAAATGCTGTATCAAAACAAAGTTTCAACTCTGTTAGTTGAGGACACACATCACAAATAAGTTTGAGGATGCTTCTGTCTAGTTTTTATTCGAAGCCAACTGGATCCTGCGCGGGACGTCCTTCGTTCGGTCCCTTCGAC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
Curate