Basic Information
VIS ID
TVIS10000522
Fusion event
HBV-ECPAS integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr9
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
114187443/111425163 (Hg38)
End
114187443/111425163 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA9E
Target gene
ECPAS
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-26b-5p ; hsa-mir-16-5p ; hsa-mir-320a ; hsa-mir-185-5p ; hsa-mir-770-5p ; hsa-mir-377-3p
Nearest miRNA
hsa-let-7a-1/Upstream/153949; hsa-mir-12126/Downstream/506937;
Nearest TSS
ENST00000422679/Upstream/53375; ENST00000374374/Downstream/58516;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/386068, chr9-CpG: 230/Downstream/57601
Upstream sequence
GGAGACCTCCGTGA
Downstream sequence
TGCAACTAGAGCAAAACTCCATTTCAAAAAAAAAAAAAGATATAGTAAGACCTCATATCAGTTTTTAACAGTTATTTCCCCCCAAAAAAGCAAAAAAGGGCAGTAATTTCTGAAATTTGTACTATTTCAAGTAAAAGGTTAAGGA
Junction sequence
GGAGACCTCCGTGAACGCCCCCCAGGTTTTGCAACTAGAGCAAAACTCCATTTCAAAAAAAAAAAAAGATATAGTAAGACCTCATATCAGTTTTTAACAGTTATTTCCCCCCAAAAAAGCAAAAAAGGGCAGTAATTTCTGAAATTTGTACTATTTCAAGTAAAAGGTTAAGGA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
Curate