Basic Information
VIS ID
TVIS10000531
Fusion event
HBV-chr11 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr11
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
69572603/69757835 (Hg38)
End
69572603/69757835 (Hg38)
Fragile sites / regions
FRA11H ; FRA11A
Nearest miRNA
hsa-mir-10392/Upstream/674577; hsa-let-7a-2/Downstream/526120;
Nearest TSS
ENST00000527297/Upstream/53193; ENST00000534086/Downstream/17329;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/52674, chr11-CpG: 196/Downstream/16223
Nearby gene
FGF19(-53497) ; FGF4(+15194) ;
Nearest cancer related gene
FGF4(OG, +15194) ;
Downstream sequence
TTTAAGTTCTGCCCCCTTAGCAGGGGTTGTTTTATGCCAAGTGTTGGCCTTGCCATCCTTGGTCATTG
Target sequence
TTTCAAATAAAGAAATATTCCCGCTTTATCACCAAATACATTATAATGTTAATCATGAAATCACAAATCATGGAATTTTAAAAGCCCCTTAGCAAACAGATAAAACAATCAGATAAATTTTGATAAATTTAAAAATCTGATGCACTCACCCCTCCCATACCCAGAATATGATAACCCTTC
Junction sequence
TTGTTCCCAAGAATATGGTGACCCGCAAAATGAGGCGCTACGTGTGGACTCTCTTTTATATAAGATCCCCGCCTTCCAAAGAGTGTGTAAATAATGGTTTTAAGTTCTGCCCCCTTAGCAGGGGTTGTTTTATGCCAAGTGTTGGCCTTGCCATCCTTGGTCATTG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
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