ZNF423 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000534
Fusion event
HBV-ZNF423 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr16
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
49739640/49705729 (Hg38)
End
49739640/49705729 (Hg38)
Location type
Intronic
Target gene
ZNF423
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-17-3p ; hsa-mir-135b-3p ; hsa-mir-140-3p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-6783-5p ; hsa-mir-6824-5p ; hsa-mir-873-5p
Nearest miRNA
hsa-mir-1225/Upstream/15542056; hsa-mir-11401/Downstream/586887;
Nearest TSS
ENST00000527434/Upstream/41504; ENST00000567712/Downstream/74880;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/6928, chr16-CpG: 58/Downstream/132809
Downstream sequence
TAAAAAGACAAAGATTAGCCTGG
Junction sequence
TCCTCCCAGTCCTTAAACAAACAGTCTTTGAAGTATGCCTCAAGGTCGGTCGTTGACATTGCGGCGAGTCCAAGAGTCCGCTTATATAAGACCTTGGGCAAGACCTGGTGGGCGTTCACGGTTAAAAAGACAAAGATTAGCCTGG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
Curate