UNC5D _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000544
Fusion event
HBV-UNC5D integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr8
Cytoband
p12
Reference genome
GRCh37/hg19
Start
35280415/35422897 (Hg38)
End
35280415/35422897 (Hg38)
Location type
Intronic
Target gene
UNC5D
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-527 ; hsa-mir-518a-5p ; hsa-mir-548aw ; hsa-mir-5195-3p ; hsa-mir-145-5p ; hsa-mir-4328 ; hsa-mir-129-5p
Nearest miRNA
hsa-mir-124-1/Upstream/5465549; hsa-mir-10400/Downstream/5848151;
Nearest TSS
ENST00000518652/Upstream/187122; ENST00000474634/Downstream/121495;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/186304, chr8-CpG: 351/Downstream/2271529
Nearest cancer related gene
UNC5D(TSG, No orient, 0)
Downstream sequence
GTCACATGGGTAGATGTTATATTGGAGGCTCTCAAATGCCCCACAGATGAAGAAACAAAGCCTCCACAA
Junction sequence
GATCCTTGTTGGGGTTGAAGTCCCAATCTGGATTGTTTGAGTTGGCTCCGAATGCAGGGTCCAACTGGTGATCGGGAAAGAATCCCAGAGGATTGGGAACAGAAAGATTTGTCCCCATGCCTTGTCGAGGTTTGGAAGACCAACCTCCCATGCTGTAGCTCTTGTTACCAAGAATATGGTGACCCACAAAATGAGGTCACATGGGTAGATGTTATATTGGAGGCTCTCAAATGCCCCACAGATGAAGAAACAAAGCCTCCACAA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
Curate