KCNH5 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000551
Fusion event
HBV-KCNH5 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr14
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
63214814/62748096 (Hg38)
End
63214814/62748096 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA14B
Target gene
KCNH5
miRNAs that regulate target gene
hsa-mir-514b-5p ; hsa-mir-513c-5p ; hsa-mir-5704 ; hsa-mir-3926 ; hsa-mir-548o-3p ; hsa-mir-1295b-3p ; hsa-mir-1323 ; hsa-mir-15a-3p ; hsa-mir-4717-5p ; hsa-mir-5582-3p
Nearest miRNA
hsa-mir-208a/Upstream/2099385; hsa-mir-1185-1/Downstream/1346928;
Nearest TSS
ENST00000550708/Upstream/608123; ENST00000557133/Downstream/297090;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/630535, chr14-CpG: 96/Downstream/297193
Upstream sequence
AGAGGGTGATTCTGGTTACAGGAAAGGGGTCCCGATCCAGACCCCAAGAGAGGGTTCTTTGATCTTGCACCAGGTGAAGCGAAGTGCACACGGTCCGGCAGATGAGAAGGCA
Junction sequence
AGAGGGTGATTCTGGTTACAGGAAAGGGGTCCCGATCCAGACCCCAAGAGAGGGTTCTTTGATCTTGCACCAGGTGAAGCGAAGTGCACACGGTCCGGCAGATGAGAAGGCACAGACGGGGAGACCGCGTAAAGAGAGGTGCGCCCCGTGGTCGGCCGGAACGGCAGACGAAGAAGGGGACGGAAGAGTCCCAATCGACCCCGAGACGGGTCGTCCGCGGGATTCAGCGCCGACGGGACGTAGACAAAGGACGT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
Curate