Fusion event
HBV-TERT integration
Detection method
PCR and Sanger sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
End
1292007/1291892 (Hg38)
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-4635/Upstream/228918; hsa-mir-10397/Downstream/17418;
Nearest cancer related gene
Upstream sequence
TGAAATGCTGCGTCTTGCGTGACTGGAAGTCCCTACCCATCGAACGGCAGCTGCCTCACACCTGCTGCGGCTCAGGTGGACCACGCCGAGTCAGATAAGCGTCATGCAACCCAGTTTTGC
Junction sequence
TGAAATGCTGCGTCTTGCGTGACTGGAAGTCCCTACCCATCGAACGGCAGCTGCCTCACACCTGCTGCGGCTCAGGTGGACCACGCCGAGTCAGATAAGCGTCATGCAACCCAGTTTTGCTTTTTGTGCCCTGAGCCTGAGGGCTCCACCCCAAAAGATTGCCGTGTGGTGGAGTGAACCCTGGCCCGAAGGATCCCACTCCTACC
* Color:
Human Sequence
/
Virus Sequence
/
Overlapped sequence
/
Unknown sequence
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.