FHIT _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000582
Fusion event
HBV-FHIT integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr3
Cytoband
p14.2
Reference genome
GRCh37/hg19
Start
61174446/61188772 (Hg38)
End
61174446/61188772 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA3B
Target gene
FHIT
miRNAs that regulate target gene
hsa-mir-143-3p ; hsa-mir-217 ; hsa-mir-331-3p ; hsa-mir-625-5p
Nearest miRNA
hsa-let-7g/Upstream/570902; hsa-mir-12124/Downstream/6036692;
Nearest TSS
ENST00000440867/Upstream/1107932; ENST00000475527/Downstream/62612;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/2138554, chr3-CpG: 48/Downstream/62160
Nearest cancer related gene
FHIT(TSG, No orient, 0)
Downstream sequence
TTCAATACACTCAAATCAATAAATGTAATCCAGCATATAAACAGAACCAAAGACAAAAACCACATGATTATCTCAATAGATGCAGAAAAGGCCTTTGACAAAATTCAACAACCCTTCATGCTAAAAACTCTCAAAAAATGAGGTATTGATGGGACATATCTCAAAATAATAAGAGCTATCTATGACA
Junction sequence
CCATCAAGGATCACTGGCCAGAGGCAAATCAGGTAGGAGCGGGAGCATTCGGGCCAGGGTTCACCCCACCACACGGCGGTCTTTTCAATACACTCAAATCAATAAATGTAATCCAGCATATAAACAGAACCAAAGACAAAAACCACATGATTATCTCAATAGATGCAGAAAAGGCCTTTGACAAAATTCAACAACCCTTCATGCTAAAAACTCTCAAAAAATGAGGTATTGATGGGACATATCTCAAAATAATAAGAGCTATCTATGACA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
Curate