Basic Information
VIS ID
TVIS10000590
Fusion event
HBV-chr11 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr11
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
60274903/60507430 (Hg38)
End
60274903/60507430 (Hg38)
Location type
Intronic
Target gene
MS4A12 ; MS4A13
Nearest miRNA
hsa-mir-129-2/Upstream/298274; hsa-let-7a-2/Downstream/1001166;
Nearest TSS
ENST00000527297/Upstream/14630; ENST00000527948/Downstream/7983;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/609046, chr11-CpG: 21/Downstream/7880
Downstream sequence
GAGCCTTTTTCAGTATGTTTAAAAAATTAATTTTGATTTGATATTGGTTGTAGAGCAGTAGA
Target sequence
TCTTTCATCTACTGGACAGAGTTCGAGAGTCCTCT
Junction sequence
GTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAAACCACCGTGAACGCCCACAGGAACCTGCCCAAGGTCTTGCATAAGAGGACTCTTGGACTTTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTGTGTTTACTGAGCCTTTTTCAGTATGTTTAAAAAATTAATTTTGATTTGATATTGGTTGTAGAGCAGTAGA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
Curate