Basic Information
VIS ID
TVIS10000640
Fusion event
HBV-chr17 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr17
Cytoband
q22
Reference genome
GRCh37/hg19
Start
56117112/58039751 (Hg38)
End
56117112/58039751 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA17B
Nearest miRNA
hsa-mir-10226/Upstream/1148396; hsa-mir-1250/Downstream/291481;
Nearest TSS
ENST00000595228/Upstream/32405; ENST00000579991/Downstream/43453;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/31739, chr17-CpG: 113/Downstream/43531
Nearby gene
SRSF1(-32405) ; DYNLL2(+43668) ;
Nearest cancer related gene
SRSF1(OG, -32405) ;
Upstream sequence
agtgtcagtccactgccagcttctctggctcaTGTGCCTGAGGCTGGTGGGATTCTGCGCACTGGGGGAAGTGTGTGAACAGGTCAGAGGGAAACTTGAA
Downstream sequence
GCCTGTTCAGGGCCAATAAAGAGAGAGGTGCAGCCACAGAAGAAGGAGGGCTGTATGGGAGAAAAGCCCCAGAGAAGATCAAAAAGGTAGACGAGTTGAG
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
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