Basic Information
VIS ID
TVIS10000675
Fusion event
HBV-chr19 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr19
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
11477600/11366924 (Hg38)
End
11477600/11366924 (Hg38)
Location type
Promoter;downstream
Fragile sites / regions
FRA19B
Target gene
PLPPR2 ; SWSAP1
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-548e-5p ; hsa-mir-6835-3p ; hsa-mir-640 ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-6075 ; hsa-mir-5699-3p ; hsa-mir-4421 ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-378a-5p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-3653-5p ; hsa-mir-1273f ; hsa-mir-1289 ; hsa-mir-129-5p ; hsa-mir-143-3p ; hsa-mir-3198 ; hsa-mir-4294 ; hsa-mir-4309 ; hsa-mir-4315 ; hsa-mir-4534 ; hsa-mir-4708-5p ; hsa-mir-4770 ; hsa-mir-4790-5p ; hsa-mir-6088 ; hsa-mir-6514-5p ; hsa-mir-6879-3p ; hsa-mir-8055 ; hsa-mir-8082
Nearest miRNA
hsa-mir-1181/Upstream/253390; hsa-let-7e/Downstream/128620;
Nearest TSS
ENST00000633603/Upstream/5658; ENST00000312423/Downstream/7761;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/4246, chr19-CpG: 39/Downstream/7686
Upstream sequence
acaataaATTTCTGatttatttatttatttattttgagacggagtctcgctctgttacctgggctggagtgcagtggtgcgacctcggctcaccgcaacc
Downstream sequence
tccaccttccaggttcaagcgattctcctgcctcactcagcctcctgagtagctgggactacaggtgcgcaccaccacgcccagctaattttttgtattt
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
Curate