Basic Information
VIS ID
TVIS10000689
Fusion event
HBV-chr13 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr13
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
59828449/59254315 (Hg38)
End
59828449/59254315 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA13B ; FRA13C
Nearest miRNA
hsa-mir-1297/Upstream/4079767; hsa-mir-1267/Downstream/1945483;
Nearest TSS
ENST00000623511/Upstream/1021198; ENST00000435636/Downstream/441878;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/1619519, chr13-CpG: 52/Downstream/909211
Nearby gene
PCDH17(-1525384) ; DIAPH3(+411272) ;
Nearest cancer related gene
PCDH17(TSG, -1525384) ;
Upstream sequence
GAGAGGTTTTGAGCACTATACAAAGAGCGCTCTTATTTTTTACCCCAAGTCAATCTTCCACAGGGCAGATTCTGAGTAGTTGTCTCCATCAGCATCAAGG
Downstream sequence
AACACATTCCCAAACTCAGACAGAGGTAGAACAGAGAGATAGAATGGCAAGCACATCTGTCAAGAAGAGGGGCCCAGTTCTGTGGATGCGGTTAGAGACA
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
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