Basic Information
VIS ID
TVIS10000695
Fusion event
HBV-chr10 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr10
Cytoband
q23.31
Reference genome
GRCh37/hg19
Start
89995347/88235590 (Hg38)
End
89995347/88235590 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA10D
Target gene
LOC101929727 ; RNLS
miRNAs that regulate target gene
hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-4708-3p ; hsa-mir-892c-5p ; hsa-mir-9500 ; hsa-mir-6822-5p ; hsa-mir-6750-5p ; hsa-mir-5584-5p ; hsa-mir-4735-3p ; hsa-mir-18b-5p ; hsa-mir-18a-5p ; hsa-mir-548n
Nearest miRNA
hsa-mir-1265/Upstream/731636; hsa-mir-107/Downstream/827745;
Nearest TSS
ENST00000439456/Upstream/283391; ENST00000526923/Downstream/347600;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/371262, chr10-CpG: 61/Downstream/347181
Nearby gene
PTEN(-266815) ; RNLS(+38274) ;
Upstream sequence
tacatgtaatatattactcaatATGAATGAATGGCATTTTTCTGGATAATATTATCATATCAACTTCAAGATTAAGAATGTGGTCAAGTCAATTTATACA
Downstream sequence
ACCCCACTTCATCCACCCCTCCACCTAGATTCAAAAATTCTTCCATTGGTATTACAAAGTCTACTTTTTGTTCCCCTTCAGATTGTTTTCATTGATATGC
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
Curate