Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000712
Fusion event
HBV-SH2B3 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr12
Cytoband
q24.12
Reference genome
End
111880825/111443021 (Hg38)
Location type
Intronic
Fragile sites / regions
Target gene
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-30b-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-26b-5p ; hsa-mir-877-3p ; hsa-mir-452-3p ; hsa-mir-3159 ; hsa-mir-6165 ; hsa-mir-576-3p ; hsa-mir-7703 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-563 ; hsa-mir-380-5p ; hsa-mir-4793-3p ; hsa-mir-6849-3p ; hsa-mir-766-3p ; hsa-mir-1273g-3p ; hsa-mir-3940-3p ; hsa-mir-508-5p ; hsa-mir-500a-3p ; hsa-mir-767-5p ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-367-3p ; hsa-mir-363-3p ; hsa-mir-32-5p ; hsa-mir-25-3p ; hsa-mir-5584-3p ; hsa-mir-129-5p ; hsa-mir-6885-3p ; hsa-mir-6875-3p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-1273e ; hsa-mir-6805-3p ; hsa-mir-5691 ; hsa-mir-6868-3p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-6826-3p ; hsa-mir-1289 ; hsa-mir-4327 ; hsa-mir-4778-3p ; hsa-mir-1236-3p ; hsa-mir-1248 ; hsa-mir-1237-3p ; hsa-mir-6832-3p ; hsa-mir-4433b-3p
Nearest miRNA
hsa-let-7i/Upstream/138812; hsa-mir-1178/Downstream/356813;
Nearest CpG islands
Nearest cancer related gene
SH2B3(TSG, No orient, 0)
Upstream sequence
AAAGCCAGTAACAGACCCCACTCAAGCTGGTTATGAGGACCTGGCAGGGTGGGGTGTGGCCCAGTACCTCGGAAGACTCTAGAAGGACCATCCTGGCCCT
Downstream sequence
ATAAATGTTTGTGCCAAGACAGGTCCCCTGTCCCTCAGCACACAGAAGGGGCAGTAGGTAGCAAGACAGTTTCCAGGTAACAGCATGAGGGCAAGTGAGG
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.