Basic Information
VIS ID
TVIS10000875
Fusion event
HBV-DEC1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr9
Cytoband
q33.1
Reference genome
GRCh37/hg19
Start
118066667/115304388 (Hg38)
End
118066667/115304388 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA9E ; FRA9B
Target gene
DEC1
miRNAs that regulate target gene
hsa-mir-26b-5p
Nearest miRNA
hsa-let-7a-1/Upstream/1094859; hsa-mir-12126/Downstream/4940591;
Nearest TSS
ENST00000422679/Upstream/12540; ENST00000614246/Downstream/95958;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/692592, chr9-CpG: 77/Downstream/849695
Nearest cancer related gene
DEC1(TSG, No orient, 0)
Upstream sequence
AAAGCCAggctgggcgtggtggctcacgcctgtaatcctagcactttgggaggctgaggcaggtggatcatgaggtcaggagttcaagaccagcttggcc
Downstream sequence
ATTATGCTTGGATTTTACTTAAGATGTTTAAAATTAAGATTTTTTTGCCATCTGTAACTTTATTTTATTGTACATTTTTTGGAGTGGGGATCTTATGTTA
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
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