Basic Information
VIS ID
TVIS10000957
Fusion event
HBV-chr11 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr11
Cytoband
q14.2
Reference genome
GRCh37/hg19
Start
85881723/86170681 (Hg38)
End
85881723/86170681 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA11F
Nearest miRNA
hsa-mir-10392/Upstream/4279845; hsa-let-7a-2/Downstream/107652;
Nearest TSS
ENST00000527297/Upstream/100799; ENST00000533228/Downstream/22801;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/101326, chr11-CpG: 18/Downstream/73662
Nearby gene
PICALM(-100800) ; EED(+74083) ;
Nearest cancer related gene
EED(TSG, +74083) ;
Upstream sequence
aaaagacaattagtaacttacttaaggttatacagcttgtgagtccctatctgggattcaaacctaggactgcctgacaccaaattttatggtttGCTTT
Downstream sequence
ATGtttttttttttttttttttttttttttttttttttttttttttttttttgagacaatcttgctctgtcacccaggctagagtgcagtggtgtgatct
Target sequence
GGATCACGTGGCTATAGACAGCGGCCAGGGCTGCCCCGCAGGCGGGCTCCACCAGGATCTTCTCATCATCTGCCAGAGAAGGGGCGTGACAGGGGCGTGGCCTGAGTTTCCCAGGGTGCACAG
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
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