Basic Information
VIS ID
TVIS10001091
Fusion event
HBV-METAP1D integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr2
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
172911286/172046558 (Hg38)
End
172911286/172046558 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA2G
Target gene
METAP1D
Nearest miRNA
hsa-mir-128-1/Upstream/3463540; hsa-mir-10b/Downstream/3121075;
Nearest TSS
ENST00000437798/Upstream/24759; ENST00000392582/Downstream/15015;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/46442, chr2-CpG: 36/Downstream/33702
Upstream sequence
TAAGATATTAGGACTAACTATAGCATTAAATATTAAACTCTTCAAATGGTAATTGTCAGTAAAAACAACTTTTAAACCAAAACAACTAGTAGCATTTCTG
Downstream sequence
CTTTAGTAGTTAATTAGAGGAAGTGGAGGTGGTTGCATGCAACAGTATTAATTTAAGAAAAGTCTTTATGTGAAAGTGTCTGTTAATATTACTTGACTAT
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
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