Basic Information
VIS ID
TVIS10001173
Fusion event
HBV-chr8 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr8
Cytoband
p23.1
Reference genome
GRCh37/hg19
Start
6884070/7026548 (Hg38)
End
6884070/7026548 (Hg38)
Location type
Promoter;downstream
Target gene
DEFA1 ; DEFA11P ; DEFA1B ; DEFA3
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-26b-5p
Nearest miRNA
hsa-mir-3674/Upstream/281304; hsa-mir-10400/Downstream/1062393;
Nearest TSS
ENST00000518652/Upstream/8247; ENST00000529559/Downstream/30186;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/190935, chr8-CpG: 81/Downstream/65279
Upstream sequence
CCTGAGTTGAGTATGTTGTGAGTGAGATTTCAGTTGTGTCACATCACAGGGATTGTGCAGCTGTTATCTCAGTCTAATTGCTACATGAGGAGGATGAAAT
Downstream sequence
TTTATTCAAAAAATGTATTGTGGAATCACAAACTAGCACTACTAAATTTAAAGTAAAATAAAGACTCTGGGGCTCACGCTAGAATACTTCCCGGGGCTCT
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
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