Basic Information
VIS ID
TVIS10001361
Fusion event
HBV-chr1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr1
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
161735926/161766136 (Hg38)
End
161735926/161766136 (Hg38)
Location type
Promoter;downstream
Target gene
ATF6 ; DUSP12
miRNAs that regulate target gene
hsa-mir-503-5p ; hsa-mir-424-5p ; hsa-let-7b-5p ; hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-191-5p ; hsa-mir-199a-5p ; hsa-mir-552-5p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-6871-5p ; hsa-mir-208b-5p ; hsa-mir-208a-5p ; hsa-mir-7153-3p
Nearest miRNA
hsa-mir-101-1/Upstream/538875; hsa-mir-1182/Downstream/390971;
Nearest TSS
ENST00000473358/Upstream/13737; ENST00000476437/Downstream/91;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/15850, chr1-CpG: 28/Downstream/217690
Nearest cancer related gene
DUSP12(OG, No orient, 0)
Upstream sequence
CAGAAAGGGGCTTTACTTTTTATTTTTAATATTATTGATAAACTTTGTTTAGTCGAATTGATGTCTGCGTGTCTTCCCCCGCCTTCCCCATAAAACAGCG
Downstream sequence
GGACAGAAAGTCCTGAAAACTCCAAAAGGGAAATATTTACTCAGAGGTCTATTCAAATTTGCTTAGTCTCTGACGTTTTCCTGTGTCGTACAAATCCCTC
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
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