Basic Information
VIS ID
TVIS10001371
Fusion event
HBV-chr12 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr12
Cytoband
p13.33
Reference genome
GRCh37/hg19
Start
324159/214993 (Hg38)
End
324159/214993 (Hg38)
Location type
Promoter;downstream
Target gene
SLC6A12 ; SLC6A13
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-342-3p ; hsa-mir-421 ; hsa-mir-4709-5p
Nearest miRNA
hsa-let-7i/Downstream/1445322;
Nearest TSS
ENST00000382841/Upstream/423; ENST00000537453/Downstream/9438;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/10828, chr12-CpG: 37/Downstream/173939
Upstream sequence
tttgcggggttgctgtgagggtgcagggatatcatAGGTGCTTAAGGGGAGGTGTGGGTGTTTGTTGTGTGTCCTCTGGAAGCAGAGGCTGGGATGGTGG
Downstream sequence
GGTGTCTGGTCCCAGGCACCTCTGGTCACTGCATAGCACCAGGCACCTAGCTAGAATTTGTCTGGAGTGGCCTGCCAGCTATCAATGGGGAAGGGTATTT
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
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