Basic Information
VIS ID
TVIS10001411
Fusion event
HBV-PAXBP1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr21
Cytoband
q22.11
Reference genome
GRCh37/hg19
Start
34144166/32771855 (Hg38)
End
34144166/32771855 (Hg38)
Location type
UTR5
Target gene
PAXBP1
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-421 ; hsa-mir-196b-5p ; hsa-mir-27b-3p ; hsa-let-7d-5p ; hsa-let-7a-5p ; hsa-mir-4775 ; hsa-mir-32-3p ; hsa-mir-548c-3p
Nearest miRNA
hsa-let-7c/Upstream/2396477; hsa-mir-3197/Downstream/778807;
Nearest TSS
ENST00000624081/Upstream/63; ENST00000477513/Downstream/3;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/25, chr21-CpG: 17/Downstream/206563
Upstream sequence
GGAGCTCCAGCCGGGTCGAGTCCTCTGTTGCTACCGCGCACCCCACGAGCGCGCATGCGCCTATGCTCCCACGCGCTCTCAATACTTGgagaaagagaga
Downstream sequence
gagtgagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagagcgagaga
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
Curate