Basic Information
VIS ID
TVIS10001413
Fusion event
HBV-chr9 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr9
Cytoband
q34.11
Reference genome
GRCh37/hg19
Start
130620101/127857822 (Hg38)
End
130620101/127857822 (Hg38)
Location type
Promoter;downstream
Target gene
AK1 ; ENG
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-769-5p ; hsa-mir-17-5p ; hsa-mir-1228-5p ; hsa-mir-6816-5p ; hsa-mir-3196 ; hsa-mir-3180-3p ; hsa-mir-3180 ; hsa-mir-486-3p ; hsa-mir-6721-5p ; hsa-mir-25-5p ; hsa-mir-4763-3p ; hsa-mir-1207-5p ; hsa-mir-658 ; hsa-mir-6722-3p ; hsa-mir-1909-3p ; hsa-mir-6823-5p ; hsa-mir-4781-5p ; hsa-mir-129-5p ; hsa-mir-8055 ; hsa-mir-6805-3p ; hsa-mir-5691 ; hsa-mir-6864-3p ; hsa-mir-3672 ; hsa-mir-431-5p ; hsa-mir-6879-3p ; hsa-mir-4294 ; hsa-mir-3194-3p ; hsa-mir-924 ; hsa-mir-215-3p ; hsa-mir-6773-3p ; hsa-mir-500b-3p ; hsa-mir-342-5p
Nearest miRNA
hsa-let-7a-1/Upstream/71815; hsa-mir-12126/Downstream/11593;
Nearest TSS
ENST00000422679/Upstream/3066; ENST00000608805/Downstream/14891;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/3243, chr9-CpG: 49/Downstream/19637
Upstream sequence
ggaactagggcctagaatggggtccttatggcttgtctggtgcccttactctactgtggctgagctgatatccagtgtaagacaaagcattctttactgt
Downstream sequence
gggtccgtcttccagccccttccctgcagggtcactgcatactggtggcctccctccactgaaggccacggtcctgttggggaccccctccacccagctc
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
Curate