Basic Information
VIS ID
TVIS10001442
Fusion event
HBV-chr17 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr17
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
18684279/18780966 (Hg38)
End
18684279/18780966 (Hg38)
Location type
Promoter;downstream
Target gene
FBXW10 ; TVP23B
miRNAs that regulate target gene
hsa-mir-25-3p ; hsa-mir-651-3p ; hsa-mir-875-3p ; hsa-mir-4323 ; hsa-mir-3692-5p ; hsa-mir-3978 ; hsa-mir-5699-5p ; hsa-mir-6793-3p ; hsa-mir-1287-3p ; hsa-mir-1287-5p ; hsa-mir-3135b ; hsa-mir-6769a-3p ; hsa-mir-3943 ; hsa-mir-5582-3p
Nearest miRNA
hsa-mir-1253/Upstream/440080; hsa-mir-10226/Downstream/563540;
Nearest TSS
ENST00000595228/Upstream/11489; ENST00000582288/Downstream/29;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/98450, chr17-CpG: 42/Downstream/246
Upstream sequence
AAGTAATACTGTACAGGAGTAAGTCTTTGtaaaatatttaaagaaaattatattatacaataaaaCCCCGCCCCCCTGCATTCGGGGCAGCGACACTGGG
Downstream sequence
GGAACGACTTTAGAATTTGCATTGGGTGGACAGCAAATACTTCCGTAAAACAGACCATGAAGCTTTCCACTTAGAGCCCACTGTGGCCCCAATACCTTTC
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
Curate