Basic Information
VIS ID
TVIS10001475
Fusion event
HBV-VXN integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr8
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
67396277/66484042 (Hg38)
End
67396277/66484042 (Hg38)
Location type
Promoter
Target gene
VXN
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-361-5p ; hsa-mir-6740-3p ; hsa-mir-924 ; hsa-mir-4778-3p ; hsa-mir-759 ; hsa-mir-6866-3p ; hsa-mir-188-5p ; hsa-mir-2115-3p ; hsa-mir-3074-3p ; hsa-mir-5007-5p ; hsa-mir-6821-3p ; hsa-mir-3942-3p ; hsa-mir-6790-3p ; hsa-mir-150-5p ; hsa-mir-186-3p ; hsa-mir-224-5p
Nearest miRNA
hsa-mir-124-1/Upstream/2104785; hsa-mir-10400/Downstream/8064501;
Nearest TSS
ENST00000518652/Upstream/10164; ENST00000488582/Downstream/9166;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/44438, chr8-CpG: 29/Downstream/21311
Upstream sequence
TCCATTATTCATGGAAATGTTTTCACAATGCACACACAAACACACATACACAAAATAGCTATATTCTACATGTCTCTACTTATAAGTATGTGTAGGTAgg
Downstream sequence
aagaaagcctcTTTTTtttgttgtttgtttgtttttttgtttgtttgtttgtttgtttgtttgagatgaagtctcgctctgtcgcccaggctggagtgca
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
Curate