Basic Information
VIS ID
TVIS10001490
Fusion event
HBV-chr3 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr3
Cytoband
q24
Reference genome
GRCh37/hg19
Start
147826592/148108805 (Hg38)
End
147826592/148108805 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/13670899; hsa-mir-1224/Downstream/3457071;
Nearest TSS
ENST00000440867/Upstream/15630; ENST00000477153/Downstream/52106;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/684201, chr3-CpG: 56/Downstream/588850
Nearby gene
ZIC1(-692086) ; AGTR1(+589066) ;
Nearest cancer related gene
ZIC1(TSG, -692086) ; AGTR1(TSG, +589066) ;
Upstream sequence
TTCTGCAGATAAACACCAATGAGACAAAAAAACACAAATAAGAAAAATGACAGAAAAGAAGAACCTTCCCAGAAGCCTCCTGCCAGTGAACGGCCACCAT
Downstream sequence
GCAAATTGACCTAAAAGTTCTATAACAACGTTTTCAGGAAGGTTACCTTAAGTCTTCAAAGAATTTTGTCTTAATTGTTAGGCCATATCATTCTTTCGAG
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
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