MAT2B _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10001508
Fusion event
HBV-MAT2B integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr5
Cytoband
q34
Reference genome
GRCh37/hg19
Start
162944407/163517401 (Hg38)
End
162944407/163517401 (Hg38)
Location type
Intronic
Target gene
MAT2B
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-155-5p ; hsa-mir-26b-5p ; hsa-let-7b-5p ; hsa-mir-21-3p ; hsa-mir-377-3p ; hsa-mir-5692a
Nearest miRNA
hsa-mir-10397/Upstream/3031951; hsa-mir-103a-1/Downstream/4648444;
Nearest TSS
ENST00000502646/Upstream/184; ENST00000522426/Downstream/692230;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/11461, chr5-CpG: 17/Downstream/3461078
Upstream sequence
ccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccct
Downstream sequence
AGTAGGAATTTGATTTTAGATATCTTGTGGAGACCTTTCCAGAAAAAGAGGGTTGCCTTTTAGTTCCTGGACCTTATTTTAAGTAAGCTTTTTGGTCAAA
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
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