Basic Information
VIS ID
TVIS10001600
Fusion event
HBV-SPECC1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr17
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
19942615/20039302 (Hg38)
End
19942615/20039302 (Hg38)
Location type
Intronic
Target gene
SPECC1
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-186-5p ; hsa-mir-10a-5p ; hsa-mir-3613-3p ; hsa-mir-3976 ; hsa-mir-5007-5p ; hsa-mir-4717-3p ; hsa-mir-6871-5p ; hsa-mir-449b-3p ; hsa-mir-5698 ; hsa-mir-377-3p ; hsa-mir-143-5p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-6847-3p ; hsa-mir-6499-3p ; hsa-mir-103b ; hsa-mir-4438 ; hsa-mir-6768-5p
Nearest miRNA
hsa-mir-1180/Upstream/694728; hsa-mir-10226/Downstream/7254608;
Nearest TSS
ENST00000595228/Upstream/22157; ENST00000580934/Downstream/34263;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/29206, chr17-CpG: 117/Downstream/116413
Upstream sequence
tacttgaaaagaatgtttattttgctattgttgggtagagtgttccgtaaatgtctattagatcctgttgttcagtggtgttaagttcttctcaactcca
Downstream sequence
tgctgatttttttgtctagttgttctatcagttgttaagagagggtgttgaatctccaagcagaatgattgatttgcctgcttttctttcaggatctttt
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
Curate