Basic Information
VIS ID
TVIS10001601
Fusion event
HBV-FOCAD integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr9
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
20922208/20922209 (Hg38)
End
20922208/20922209 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA9C
Target gene
FOCAD
miRNAs that regulate target gene
hsa-mir-186-5p ; hsa-mir-6083 ; hsa-mir-539-3p ; hsa-mir-485-3p ; hsa-mir-190a-3p ; hsa-mir-487a-3p ; hsa-mir-154-3p ; hsa-mir-3074-3p ; hsa-mir-5011-5p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-1277-5p ; hsa-mir-5692a
Nearest miRNA
hsa-mir-101-2/Upstream/206021; hsa-let-7a-1/Downstream/589906;
Nearest TSS
ENST00000422679/Upstream/25238; ENST00000603695/Downstream/5556;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/237572, chr9-CpG: 34/Downstream/109230
Upstream sequence
GTAGAGGCTTCAGTTTCtttaaaaaaaaaaaaaaaaaaatCGggccaggtgcgatggctcacgcatgtaatcccagcactttgggaggccaaggcaggca
Downstream sequence
AGCAAAACCCAGGTTGGGGCCATCTGCTTAGACCTCAAGGCTTCCTTCCCATTTTCTCCTCCAACCCTCCCCATTATAAACGTTGATGTCTTGCTAACTT
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
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