Basic Information
VIS ID
TVIS10001688
Fusion event
HBV-PAK5 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr20
Cytoband
p12.2
Reference genome
GRCh37/hg19
Start
9785586/9804938 (Hg38)
End
9785586/9804938 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA20B
Target gene
PAK5
miRNAs that regulate target gene
hsa-mir-4776-3p ; hsa-mir-5006-5p ; hsa-mir-3972 ; hsa-mir-1202 ; hsa-mir-630 ; hsa-mir-548l ; hsa-mir-548n ; hsa-mir-129-5p ; hsa-mir-3682-5p ; hsa-mir-627-3p ; hsa-mir-138-1-3p ; hsa-mir-186-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/2433246; hsa-mir-1-1/Downstream/844698;
Nearest TSS
ENST00000382410/Upstream/229330; ENST00000449270/Downstream/33893;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/288692, chr20-CpG: 47/Downstream/33685
Nearest cancer related gene
PAK5(OG, No orient, 0)
Upstream sequence
aggagtttaggaccagcctgggcaacacagtgcgaccttgtctctattaaaaGAAAAcaacaaacaaacaaaaacagcaatcaaaaaacagtgtgaaaag
Downstream sequence
gtgacccacaaaatgggataaaataatgctaatattatatctgataatggtctagtatccagaatataaaaaactcttacaactcaacaataaaacacaa
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
Curate