Basic Information
VIS ID
TVIS10001690
Fusion event
HBV-chr18 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr18
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
12990743/12990744 (Hg38)
End
12990743/12990744 (Hg38)
Location type
Promoter;downstream
Target gene
CEP192 ; SEH1L
miRNAs that regulate target gene
hsa-mir-210-3p ; hsa-mir-16-5p ; hsa-mir-301a-3p ; hsa-mir-186-5p ; hsa-mir-27b-3p ; hsa-mir-142-3p ; hsa-mir-548e-5p ; hsa-mir-3646 ; hsa-mir-5680 ; hsa-mir-4422 ; hsa-mir-6892-5p ; hsa-mir-6089 ; hsa-mir-4518 ; hsa-mir-1266-5p ; hsa-mir-3664-3p ; hsa-mir-4475 ; hsa-mir-765 ; hsa-mir-766-5p ; hsa-mir-4533 ; hsa-mir-4487 ; hsa-mir-6847-5p ; hsa-mir-6876-5p ; hsa-mir-4476 ; hsa-mir-4668-5p ; hsa-mir-3613-3p ; hsa-mir-8067 ; hsa-mir-6508-5p
Nearest miRNA
hsa-mir-3976/Upstream/1335803; hsa-mir-1-2/Downstream/469203;
Nearest TSS
ENST00000575820/Upstream/11915; ENST00000507064/Downstream/429;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/42089, chr18-CpG: 68/Downstream/318
Upstream sequence
TATGGAATAAATTTTGAGATAAGGGACCTTACTGAAAAAGACTGAGATACATTTTGAGTGAAAGGCATGGTCTCAGTGAAGTAGTTAAGGGCCTGTGCCG
Downstream sequence
AGCAGATGGCGGTGATGGGTTTTGTGGCCTAAGAAGGATGGAGAAAAGTAGGAAGCAATCGAGACAAAGCCTACTCTGTCACAAAGAGGCGACTAGATGT
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
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