Basic Information
VIS ID
TVIS10001731
Fusion event
HBV-chr22 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr22
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
43760025/43364019 (Hg38)
End
43760025/43364019 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA22A
Nearest miRNA
hsa-mir-1281/Upstream/1440722; hsa-let-7a-3/Downstream/1836935;
Nearest TSS
ENST00000624155/Upstream/20631; ENST00000450750/Downstream/36312;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/19740, chr22-CpG: 112/Downstream/47375
Nearby gene
SCUBE1(-20631) ; MPPED1(+47995) ;
Upstream sequence
CACATAATGAAAGAATGGGCCGATTCAAGGAGACCGGGGAGAGAAAAGAGGGAAAATTAGAGTTCAGTCTGCTCACTTAAAAAAAAAAGGGGGAGGGGGT
Downstream sequence
GGGGTGGAAATTGTGGATTTGCTAAATAAAGCTCCTGGCTGCATTCAGAGCTTGGGGAAGGGTCCCCCACTCAATCCTCTTAGGCCTGACAAAGTCGGAC
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
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