PRKCE _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10001736
Fusion event
HBV-PRKCE integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr2
Cytoband
p21
Reference genome
GRCh37/hg19
Start
46185749/45958610 (Hg38)
End
46185749/45958610 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
PRKCE
miRNAs that regulate target gene
hsa-mir-205-5p ; hsa-mir-1-3p ; hsa-mir-31-5p ; hsa-mir-96-5p ; hsa-mir-21-5p ; hsa-mir-342-3p ; hsa-mir-107 ; hsa-mir-146a-5p
Nearest miRNA
hsa-mir-1301/Upstream/10487124; hsa-mir-10b/Downstream/1419065;
Nearest TSS
ENST00000437798/Upstream/260628; ENST00000489067/Downstream/19485;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/306064, chr2-CpG: 289/Downstream/338040
Nearest cancer related gene
PRKCE(OG, No orient, 0)
Upstream sequence
aaaaaaaaaaaaaagaaagaaaaTCAAAACTCATAGAAACAACTCCCTTTCACACTACAATCCACCTGCCAGGGAGCACCCCCTTGAGATGTCCTGGCCT
Downstream sequence
CTCACACACCCCCTATGCTCCCTGCCATATATATTGTGGTGAGAGAGGGAGTTGTCTCTATGAGTTTTAATTTTCTATGAGTTTTAGCTTCTTCTGTGTG
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
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