MAP4K4 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10001777
Fusion event
HBV-MAP4K4 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr2
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
102459211/101842749 (Hg38)
End
102459211/101842749 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2A
Target gene
MAP4K4
miRNAs that regulate target gene
hsa-mir-520e ; hsa-mir-181a-5p ; hsa-mir-31-5p ; hsa-mir-141-3p ; hsa-mir-302c-5p ; hsa-mir-30d-5p ; hsa-let-7a-5p ; hsa-mir-5687
Nearest miRNA
hsa-mir-1285-2/Upstream/533215; hsa-mir-10b/Downstream/589540;
Nearest TSS
ENST00000437798/Upstream/2921; ENST00000418101/Downstream/13228;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/144383, chr2-CpG: 92/Downstream/299597
Upstream sequence
GAGGAAGTGCCTGAACAGGAAGGAGAGCCAAGGTAACCACAAAGCCACTGTTCAGTATCCTGCTTTATGAAGGGATTAAGTTTTATGTTGTGCCAGGACT
Downstream sequence
GCAGAAGACTCCTGTGTGGTACAAAGAATCTTAAATTACTTAGACAGCATCTTACTATCTCCATTCTTCTCTATTCTTGACAGATTCCTGTAAACATTTT
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
Curate