Basic Information
VIS ID
TVIS10001854
Fusion event
HBV-COA1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr7
Cytoband
p13
Reference genome
GRCh37/hg19
Start
43722628/43683029 (Hg38)
End
43722628/43683029 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA7D
Target gene
COA1
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-17-5p ; hsa-mir-218-5p ; hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-3153 ; hsa-mir-6077 ; hsa-mir-6783-5p ; hsa-mir-6859-5p ; hsa-mir-3916 ; hsa-mir-3125 ; hsa-mir-651-3p
Nearest miRNA
hsa-mir-1183/Upstream/532035; hsa-mir-10399/Downstream/368737;
Nearest TSS
ENST00000635602/Upstream/32733; ENST00000453612/Downstream/46445;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/99236, chr7-CpG: 64/Downstream/46186
Upstream sequence
GGCTGTGGCATGGGCATCCACAACTGTCTGCTGTGATCCTCATTCCTGTGTGCAGACTTTCTTCTCTAGCTAAACTCACTGATTTATTACTTCACAACCA
Downstream sequence
gggtttttagtagagatggggtttcaccatgttggccaggctggtctcaaattcctgacctcaagtgatctgccagcttcggcctcccaaagtgctagga
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
Curate