VISDB Viral Integration Site DataBase

VIS ID

TVIS10001890

Fusion event

HBV-ARHGEF12 integration

Validated

No

Detection method

HIVID

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1

Chromosome

chr11

Cytoband

q23.3

Reference genome

Start

End

120318374/120447665 (Hg38)

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-21-5p ; hsa-mir-1225-3p ; hsa-mir-30c-5p ; hsa-mir-6077 ; hsa-mir-7-5p ; hsa-mir-1250-3p ; hsa-mir-660-5p ; hsa-mir-362-3p ; hsa-mir-329-3p

Nearest miRNA

hsa-mir-10392/Upstream/1134653; hsa-let-7a-2/Downstream/1652092;

Nearest TSS

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/110725, chr11-CpG: 126/Downstream/63503

Nearest cancer related gene

ARHGEF12(TSG, No orient, 0)

Upstream sequence

cccagcactttgggaggccgagcgggcggattacgtaaggccaagagttcgagaccaagctggccaacatggtgaaaccccatctctactaaaaacccca

Downstream sequence

aaattagccaggcatggtggcactcctgtaatcccagctactcagaaggctgaggcacgagaatcacttgcgcccaggaggcggaggttgcagtgagcca

Target sequence

ggagtttgtagtctaatgggaaagacGTAAATTACAACCTTTTCAATTATGTAATTAGGTTTTGGACAAGTGCATTTGAGGAAGTCATCTTAGGTTGGCATGAAGTATAAATACTTagaggtgatattcaagatagttaacaatcagaacagtctacctaccaacaattaggactgatgtggggcttaaacaaTTTACACACTGGTTGAAGGTGAGCTCCTTTTGGGTGGGACCAGGCAGGAGAGGATGGTGATG