Basic Information
VIS ID
TVIS10001934
Fusion event
HBV-KDM8 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr16
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
27229423/27218102 (Hg38)
End
27229423/27218102 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA16E
Target gene
KDM8
miRNAs that regulate target gene
hsa-mir-149-5p ; hsa-mir-378c
Nearest miRNA
hsa-mir-1225/Upstream/1192792; hsa-mir-11401/Downstream/1172880;
Nearest TSS
ENST00000527434/Upstream/3109; ENST00000569592/Downstream/2216;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/13745, chr16-CpG: 35/Downstream/50463
Nearest cancer related gene
KDM8(TSG, No orient, 0)
Upstream sequence
AGACCCTGGCTTTGTGTAAAGGAGGCCAGggccatgtgcagtggctcatacctgtagtcccagcactttgggagaccaagcaggaccagcctggacaaca
Downstream sequence
tagcaagaccccatctctacaaaaataaaattagccaggcacggtggcatgctcctgtggtcccagcaatttgggaggctgaggcaggaggatcgcttaa
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
Curate