Basic Information
VIS ID
TVIS10002023
Fusion event
HBV-chr11 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr11
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
91906061/92172895 (Hg38)
End
91906061/92172895 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-10392/Upstream/1303693; hsa-let-7a-2/Downstream/1560779;
Nearest TSS
ENST00000527297/Upstream/369540; ENST00000528921/Downstream/179201;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/1949705, chr11-CpG: 204/Downstream/51574
Nearby gene
DISC1FP1(-1257841) ; FAT3(+179201) ;
Upstream sequence
taaacgagaaaatctagaagaaatggataaattcctcgacacatacactctcccaagactaaaccaggaagaagttgaatctctgaatagaccaataaca
Downstream sequence
ggagctgaaattgtggtaataatcaatagcttaccaaccaaaaagagtccaggaccagatggattcacagccaaattctaccagaggtacaaggaggaac
Target sequence
CCTTCTTACTCTGGTCCAGTGTCATCTTGGCTTCCAATCTCTTTTTTTCTCTCTCTCATCCTCCACTCCGTATTTCCCCATTAGACAGGACAACAGAAGTCAGGTTTCCAGGCTGCTGAGGGCAGCAGTTCTAAACCTTTTGTGTCCCAAATGTGTTGAATCATAGGACAAAAAGAGAGAAAGGAGTGGAGTACAATGATCTTGTTAGtgtcacctgaagaatgatgaggtttgtaaatttgaaaaggagacctt
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
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