Basic Information
VIS ID
TVIS10002027
Fusion event
HBV-chr5 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr5
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
139897855/140518270 (Hg38)
End
139897855/140518270 (Hg38)
Location type
Intronic
Target gene
ANKHD1 ; ANKHD1-EIF4EBP3
miRNAs that regulate target gene
hsa-mir-424-5p ; hsa-mir-320a ; hsa-mir-185-5p ; hsa-mir-6838-5p ; hsa-mir-6834-5p ; hsa-mir-3622b-5p ; hsa-mir-885-3p ; hsa-mir-6134 ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-6875-5p ; hsa-mir-3126-5p ; hsa-mir-5693 ; hsa-mir-4519 ; hsa-mir-4713-3p
Nearest miRNA
hsa-mir-10397/Upstream/2870621; hsa-mir-103a-1/Downstream/45401;
Nearest TSS
ENST00000502646/Upstream/8160; ENST00000475148/Downstream/5913;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/115747, chr5-CpG: 36/Downstream/29302
Upstream sequence
CCACGTGCGCAGCAGGACGCAGCGCTGCCTGAAACTCGCGCCGCGAGGAGAgggcggggccgcggaaaggaaggggaggggctgggagggcccggagggg
Downstream sequence
ggagctgaaattgtggcaataatcaatagcttaccaaccaaaaagagtccaagaccagatggattcacagccgaattctaccagaggtacaaggaggagc
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
Curate