Basic Information
VIS ID
TVIS10002053
Fusion event
HBV-chr18 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr18
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
53689152/56021921 (Hg38)
End
53689152/56021921 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA18B
Target gene
LOC107985164 ; LOC642484
Nearest miRNA
hsa-mir-1-2/Upstream/542623; hsa-mir-122/Downstream/2429153;
Nearest TSS
ENST00000575820/Upstream/23582; ENST00000589983/Downstream/20214;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/241310, chr18-CpG: 57/Downstream/616267
Nearby gene
TCF4(-385964) ; PRPF31(+61435) ;
Upstream sequence
CAAGGCTCAAGTATATCGGGCATATGGGAAGCATGTAAATGTTCAAAGAGGATGTCCAGTAATGAGGAATCCAACATTTATCCCAATAGCAACATGTTAA
Downstream sequence
ATGCTCCCACTCCCTTCTGACCATTGCTGCTCAAGTGTTTCCTTCTGAGATAATTCCTTGAAAGTGTGTGTACATGACCAGTCTCCATGGCTAACACATA
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
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