Basic Information
VIS ID
TVIS10002140
Fusion event
HBV-LRMDA integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr10
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
77234888/75475130 (Hg38)
End
77234888/75475130 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA10D
Target gene
LRMDA
Nearest miRNA
hsa-mir-1265/Upstream/2754030; hsa-mir-107/Downstream/77328;
Nearest TSS
ENST00000439456/Upstream/43542; ENST00000593817/Downstream/126110;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/43317, chr10-CpG: 19/Downstream/637195
Nearby gene
PRPF31(-63806) ; LRMDA(+307631) ;
Upstream sequence
catgttcaaatgtttCTCTTGAGAAACACTTAGTCTCCTCTGAGGACATAAGCATAAGAGCCCCATGCTGTTGCTGGGGTCCTGGGAGAGCACTGGAGAT
Downstream sequence
GAGCATCTGATGGGGCCTGATGCTGCACCCCTGGTTGGGCACATGTGGAATTCTGAAGACCCAGGAGGCCATAGTGCTTCAGTTTTCTCCCTCTGGTCCC
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
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