Basic Information
VIS ID
TVIS10002152
Fusion event
HBV-NSD3 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr8
Cytoband
p11.23
Reference genome
GRCh37/hg19
Start
38195808/38338290 (Hg38)
End
38195808/38338290 (Hg38)
Location type
Intronic
Target gene
NSD3
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-155-5p ; hsa-mir-192-5p ; hsa-mir-21-5p ; hsa-mir-196b-5p ; hsa-mir-301a-3p ; hsa-mir-10b-5p ; hsa-mir-203b-3p ; hsa-mir-7158-3p ; hsa-mir-203a-3p ; hsa-mir-526b-5p ; hsa-mir-4635
Nearest miRNA
hsa-mir-124-1/Upstream/8380942; hsa-mir-10400/Downstream/2932758;
Nearest TSS
ENST00000518652/Upstream/2309; ENST00000607047/Downstream/42531;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/68776, chr8-CpG: 160/Downstream/43381
Nearest cancer related gene
NSD3(OG, No orient, 0)
Upstream sequence
ttacaacttgagccactgagcttggccTGTTGTCTAGTATTTTAAGTCTTTTTTTTAAAAAAATTCTACAATATAGATATGACTATTGAATTATGAAATG
Downstream sequence
ctccgtctcaaaaagaaaaaaaaaaaaaaTACACATGATCAATTGAAAAAAAAACAGGTCATAGTTTTGAAAAGGAAAATGATTCACTGAAAATATCCAC
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
Curate