Basic Information
VIS ID
TVIS10002244
Fusion event
HBV-FYB1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr5
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
39137075/39136973 (Hg38)
End
39137075/39136973 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA5A
Target gene
FYB1
miRNAs that regulate target gene
hsa-mir-4795-3p ; hsa-mir-613 ; hsa-mir-206 ; hsa-mir-1-3p ; hsa-mir-126-5p ; hsa-mir-4307 ; hsa-mir-656-3p ; hsa-mir-33a-3p ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p
Nearest miRNA
hsa-mir-10397/Upstream/579412; hsa-mir-103a-1/Downstream/14814531;
Nearest TSS
ENST00000502646/Upstream/9166; ENST00000603514/Downstream/3057;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/61839, chr5-CpG: 39/Downstream/287817
Upstream sequence
CACGACCGCCATCCACAGTCACCACATCAGACCCCACGACCGCCATCCACAGTCACCACACATCAGACCCCCGGGACCAACCGCCATCCACAGTCACCAC
Downstream sequence
TAGCCCCTGAGTGTAGCGTTTACTGGTGGTAGTAATGGTAGAAAACACACAATTACCAGAGATCAGAGAATACAGAGGTCAGAATCCAGACAGACAAAGA
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
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