VISDB Viral Integration Site DataBase

VIS ID

TVIS10002314

Fusion event

HBV-NOTCH2 integration

Validated

No

Detection method

HIVID

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1

Chromosome

chr1

Cytoband

p12

Reference genome

Start

End

120543902/120001279 (Hg38)

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-1-3p ; hsa-mir-16-5p ; hsa-mir-181c-5p ; hsa-mir-326 ; hsa-mir-34a-5p ; hsa-mir-107 ; hsa-mir-155-5p ; hsa-mir-183-5p ; hsa-mir-181a-5p ; hsa-mir-744-5p ; hsa-mir-130b-5p ; hsa-mir-27b-3p ; hsa-mir-196a-5p ; hsa-mir-106a-5p ; hsa-mir-92a-3p ; hsa-mir-25-3p ; hsa-mir-17-5p ; hsa-let-7c-5p ; hsa-mir-29b-3p ; hsa-mir-6868-3p ; hsa-mir-182-5p ; hsa-mir-3124-3p ; hsa-mir-515-5p ; hsa-mir-519e-5p ; hsa-mir-3942-3p ; hsa-mir-23b-3p ; hsa-mir-205-5p ; hsa-mir-96-5p ; hsa-mir-1271-5p ; hsa-mir-5695 ; hsa-mir-519d-5p ; hsa-mir-6838-5p ; hsa-mir-4274 ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-29b-1-5p ; hsa-mir-543 ; hsa-mir-4753-3p ; hsa-mir-5100 ; hsa-mir-6794-3p ; hsa-mir-210-5p ; hsa-mir-4749-3p ; hsa-mir-1248 ; hsa-mir-1237-3p ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-10b-3p ; hsa-mir-4639-3p ; hsa-mir-146a-5p ; hsa-mir-9-3p ; hsa-mir-9-5p ; hsa-mir-191-5p

Nearest miRNA

hsa-mir-101-1/Upstream/2906551; hsa-mir-1182/Downstream/25849308;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/104682, chr1-CpG: 95/Downstream/67455

Nearest cancer related gene

NOTCH2(TSG, No orient, 0)

Upstream sequence

ttttctttccggtctcggggatatctttatcagcagcgtgaaaatggactaatacaGTAAATTGGTACCAAGAGTGGGGTTtttgccagagtgccaacta

Downstream sequence

tcccgagggaaactttggagggaaccagctactagatggttcaattagtctttcgcccctacacccaggttggatgaccgatttgcacatcaggactgct