Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10002475
Fusion event
HBV-AKAP13 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr15
Cytoband
q25.3
Reference genome
Start
End
86032860/85489629 (Hg38)
Location type
Intronic
Target gene
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-423-5p ; hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-149-5p ; hsa-mir-16-5p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-8074 ; hsa-mir-6778-3p ; hsa-mir-4287 ; hsa-mir-4685-3p ; hsa-mir-1281 ; hsa-mir-3667-3p ; hsa-mir-6832-3p ; hsa-mir-183-5p
Nearest miRNA
hsa-mir-10393/Upstream/108967; hsa-mir-11181/Downstream/280867;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/108180, chr15-CpG: 20/Downstream/269089
Nearest cancer related gene
AKAP13(OG, No orient, 0)
Upstream sequence
GGGGAAGTTCTCTGCACCTGGACAAAGAAATAAGCAAGAGAACAAAGACTGTGAAGATTTTCATTTAGATCATATTTGGGATCTGCCAGGGGTGAGTATC
Downstream sequence
ATCATTAGAAGGGAGAATATTGCTGCTAAATAAGGAAAAACACTGTACCCGGAGAAGAACTTTTATCTGTCAGTTAAGACAAATAGGCTGGACTCCAAAT
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.