PCLO _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10002504
Fusion event
HBV-PCLO integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr7
Cytoband
q21.11
Reference genome
GRCh37/hg19
Start
82689678/83060362 (Hg38)
End
82689678/83060362 (Hg38)
Location type
Intronic
Target gene
PCLO
miRNAs that regulate target gene
hsa-mir-136-5p ; hsa-mir-127-5p ; hsa-mir-432-5p ; hsa-mir-3166 ; hsa-mir-7-2-3p ; hsa-mir-7-1-3p ; hsa-mir-548e-5p
Nearest miRNA
hsa-mir-10525/Upstream/7145093; hsa-mir-10399/Downstream/9143653;
Nearest TSS
ENST00000635602/Upstream/109614; ENST00000430696/Downstream/74248;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/616158, chr7-CpG: 81/Downstream/101996
Upstream sequence
TATGACTTTGCAACTCTTTTTTCTTTTTCgaatggaatggaatggaatggaatggaatggaatggaatggaatggaatagaatggaatggaatggaattc
Downstream sequence
CTCTGCCAAAAATGCCACCTGACCTTGCTGCTCATTATTGATTACTGTCTGCTGCAGCTGCCACCAGACAAGGGCTAGAGACCTGCCCCAGACTGCTGCT
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
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