Basic Information
VIS ID
TVIS10002516
Fusion event
HBV-chr16 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr16
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
68050100/68016197 (Hg38)
End
68050100/68016197 (Hg38)
Location type
Promoter;downstream
Fragile sites / regions
FRA16B
Target gene
DDX28 ; DPEP2NB ; DUS2
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-484 ; hsa-mir-324-3p ; hsa-mir-32-5p ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-1262 ; hsa-mir-137 ; hsa-mir-25-3p ; hsa-mir-3194-5p ; hsa-mir-363-3p ; hsa-mir-367-3p ; hsa-mir-4278 ; hsa-mir-4701-3p ; hsa-mir-4710 ; hsa-mir-4711-3p ; hsa-mir-4716-3p ; hsa-mir-511-5p ; hsa-mir-6732-5p ; hsa-mir-6736-5p ; hsa-mir-6747-5p ; hsa-mir-6748-5p ; hsa-mir-6752-5p ; hsa-mir-6755-5p ; hsa-mir-6794-5p ; hsa-mir-6804-5p ; hsa-mir-6805-5p ; hsa-mir-6830-3p ; hsa-mir-6842-5p ; hsa-mir-6858-3p ; hsa-mir-7110-5p
Nearest miRNA
hsa-mir-1225/Upstream/813802; hsa-mir-11401/Downstream/217229;
Nearest TSS
ENST00000527434/Upstream/46; ENST00000569289/Downstream/6759;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/22704, chr16-CpG: 89/Downstream/6482
Upstream sequence
CTAAATTCTGATATGAGCTGGAGAGGCAAGATTAATCTAAGAGATAGATAGGTAGCCACGCACTGGTGCTAAGCAATCAACAGCAGGAGAGGCAGAGATT
Downstream sequence
GGGATGGACAAAGGGATCATGGAAGGCTCCTTCGAGCTGGACTTGAAGGACTGGTGAGATCTGGACACACGCAAAGAgtaactgcccaacgtgttcccct
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
Curate