Basic Information
VIS ID
TVIS10002778
Fusion event
HBV-chr11 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr11
Cytoband
p15.3
Reference genome
GRCh37/hg19
Start
13158769/13137222 (Hg38)
End
13158769/13137222 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-210/Upstream/973455; hsa-let-7a-2/Downstream/2832311;
Nearest TSS
ENST00000527297/Upstream/2383; ENST00000529050/Downstream/139430;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/126185, chr11-CpG: 168/Downstream/140027
Nearby gene
RASSF10(-125116) ; ARNTL(+140556) ;
Nearest cancer related gene
RASSF10(TSG, -125116) ; ARNTL(TSG, +140556) ;
Upstream sequence
cttgaacctgggaggcagaagttgcagtgagctgagatcgcgccactgcactccagcctgggtgacagagcaagactccatctcagaaacaaacaaacaa
Downstream sequence
aaTTCCTCCCTTGATTAATCTCTTTCCTTAGTTGATGCTAATAAACACATAGAGTCACTTTTATCTCTTTCAACTGCCTAAAAAAAGGTTGCTGATACCA
Target sequence
tgtccagactgttctcaaaatcctgagctcaagcgatctgcccacctcagcctcccagagtgctgggtttacagacgtgagccactgtacgaggccAGTGTTCATATTTGCTATAGTTTTATGATACCCAAAAGCTCTCACCATCTTTCAATATTCAAATTATGCATTGGGAAACATTTATGAGTAGGATGGTCAGCCATGTTATCATTGGGCCTCCACACATCGCCAGCCTGGGTATAAACATAAAATCAAACA
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
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