Basic Information
VIS ID
TVIS10002881
Fusion event
HBV-LTO1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr11
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
69483663/69668895 (Hg38)
End
69483663/69668895 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA11H ; FRA11A
Target gene
LTO1
miRNAs that regulate target gene
hsa-mir-92b-3p
Nearest miRNA
hsa-mir-10392/Upstream/585637; hsa-let-7a-2/Downstream/615060;
Nearest TSS
ENST00000527297/Upstream/497; ENST00000534086/Downstream/3027;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/14511, chr11-CpG: 58/Downstream/6091
Upstream sequence
ggagggtggatcacctgaggtcaggagttcgagaccagcctgaccaatatggtgaaaccctgtctccactaaaaatacaaaaattagatgggcgtgatag
Downstream sequence
tgtgtgcctgtagtcccagctactcgggaggctgagacaggagaattgctggaacctgggaggtggaggttgcagtgagctaagattgtgccactgcact
Target sequence
ctactaaaaatacaaaaattagccaggtgtggtggcgcatgcctgtagtcccagctactccggaggctgaggcatgaggaggtgcaggttgcactgagctgagattgcaccactgcgctccagcctgggtgacagagtgagactctgtctcaaaacaaacaaacaaacaagaaagaataaaGAGCAAAAATAGACATTGGCTCATAGAGGTATGGTCAAATTGTGCATTTATGGGCTTCATATGTTTTGCAAAGT
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
Curate