Basic Information
VIS ID
TVIS10002882
Fusion event
HBV-chr11 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr11
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
69586808/69772040 (Hg38)
End
69586808/69772040 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA11H ; FRA11A
Target gene
FGF4 ; LOC109117331
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-10392/Upstream/688782; hsa-let-7a-2/Downstream/511915;
Nearest TSS
ENST00000527297/Upstream/67398; ENST00000534086/Downstream/3124;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/66879, chr11-CpG: 196/Downstream/2018
Nearby gene
FGF19(-67702) ; FGF4(+989) ;
Nearest cancer related gene
FGF4(OG, No orient, 0)
Upstream sequence
CCTGCCTCTTCCACGGTTGCTTCAATGACAGGGGTTACATTTGTAAAATATATAAAGAAAAATATAAGGTTACTTGGTGACCATATAGTGTACTGTAACA
Downstream sequence
GCTGTCTGCAAATATTTTCACCATGATCACCCTTACTAAAAGTAAATCACAGGGTAAAGATAGCTCAAACGTGACAAGGTTCGAATGGGACGCACCGACG
Target sequence
cctaatcccactcgaagcagccctaagaaacatcacccattatctctccataccacccccaaaaaattttcaccgccccaacatttcaacactattttgttttatttttcttattaatataagaagacgggaatgtcaggcctctgagcccaagcctgcacatatacatccagatggcctgaagcaagtgaagaatcacaaaagaagtgaaaatggctggttcctgccttaactgatgacattccaccattgtga
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
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